The Science of Kambo

The first person to analyse kambo in a lab, an Italian Scientist by the name of Vittorio Erspamer, called it "a fantastic chemical cocktail with potential medical applications, unequalled by any other amphibian". Kambo has since been the subject of nearly three decades of medical research. This work consists of attempting to identify, isolate and reproduce the incredible chemical cocktail that Kambo is.

The secretion contains a multitude of peptides, which are short chains of amino acids. Examples of naturally occurring peptides in the human body include oxytocin, endorphin and insulin. Amino acids are often referred to as the building blocks of all human life. This means that kambo is made from the same basic ingredients that humans are, with an assortment of peptides, neuropeptides and biopeptides that have very specific functions in the human body.

Kambo peptides

In other words, because the kambo secretion consists of compounds our bodies are intrinsically familiar with, our bodies readily accept them and set about performing the peptides' functions to our benefit (imagine a lock, that when opened with the right key - the bioactive peptide - triggers specific chemical reactions in the body). Benefits can include things such as pain relief, anti-inflammation, detoxification (particularly the liver), immune system stimulation, hormone balance, antibacterial / anti-fungal / anti-parasitic properties, and more. It is frequently said to help with depression, anxiety, and emotional hurdles.

Kambo host defense peptides functions diagram

A deeper look into kambo's functions

While no absolute guarantees should be made, fascinating research exists around kambo and its functions, in particular one of the peptides called dermaseptin. Dermaseptin is present in many amphibian skin secretions, as a kind of antibacterial/antimicrobial protection. Such antimicrobial peptides "have been shown to enhance the overall immune response" and were reported to stimulate the microbicidal activity of leukocytes and to chemoattract leukocytes. It's also antiviral, and "plays a key role in defense mechanisms against a broad spectrum of pathogens, including enveloped viruses" - that's things like HSV, HPV, SARS, and even the dreaded Covid19.

Another example of surprising research to have emerged is this: several years of ongoing research by the University of Paris have shown the same peptide to be super effective at killing cancer cells - and Queens University in Belfast recently won a prestigious award for their groundbreaking work with cancer and frog secretions. And this is just a snippet of research from just one peptide in kambo! Keep in mind however, much of this research is in-vitro, and despite the incredible promise shown, it should not be assumed kambo will definitely cure diseases, serious or otherwise.

Kambo shaman holding the frog

There are opioid agonists such as dermorphin and deltorphin, acting with much greater strength than morphine but without toxicity or withdrawal, potentially promising powerful yet safe pain reduction.

There is phyllokinin, a powerful vasodilator which gets the blood pumping and flowing, and has shown reductions in blood pressure.

There are over 70 patents out for various compounds in kambo, but it is proving very difficult to reproduce. On top of this, several of the peptides in kambo work together in unison, further complicating efforts to isolate and reproduce the benefits of any one peptide.

Truly, it would be exhaustive to list all the peptides and the research relating to their functions, so you are encouraged to read the link below.

🐸 Read more about the science and research behind kambo here 🐸

Girl from the Amazon tribe of Yine

So what are the possible benefits of Kambo ?

Physically

Kambo kick starts a cleansing and rebalancing process, with potential for those who suffer from chronic fatigue, chronic pain, inflammation, recurrent infections, alcohol and drug addictions, fertility issues, thyroid problems, fungal issues, Lyme disease, HIV-related immune issues, herpes, gut problems, Parkinson's disease, and autoimmune conditions such as rheumatoid arthritis. Additionally, the peptide tryptophan has been shown to be highly potent against candida, and the peptide phyllokinin imparts a long-lasting reduction in blood pressure.

Mentally

People report benefits when it comes to improved cognitive health, clarity of mind, heightened awareness, overcoming mental obstacles and decisions, increased focus and a sharpening of the senses.

Emotionally

Kambo may help to reduce anxiety, depression and stress, process and heal past traumas, clear emotional baggage, enhance resilience to stress and fatigue, while boosting overall mood and well being.

  • Short term effects are said to include enhanced mood, clarity, focus, energy and increased resistance to stress, tiredness, hunger and thirst. "The mind becomes still, you feel lighter and everything becomes easier to manage". It works towards purging the lymph system and especially the liver. Other properties include kambo's anti-inflammatory effects and its capacity to destroy microbes and viruses. ​
  • In the longer term, kambo energizes the immune system and tries to bring bodily systems and functions to a normal, natural level - so that existing health problems may improve or resolve and future ones may be less likely to occur. It can be an excellent tool to overcome addictions and depression. It is common for users to report they have avoided seasonal colds, flus, and illnesses altogether - myself included!
  • There is no need to take my word for it. Though it is not a medicine by the western definition, it has been considered a 'jungle medicine' for centuries for good reason. Thousands of people worldwide will attest to the benefits it brings.